Serene Clinic

What is the difference between collagen injections and filler?

Director Kim Serim ·

Filler uses hyaluronic acid gel to create volume immediately, in proportion to the amount injected. Collagen injections deliver collagen itself or ingredients that help collagen production, so the skin fills in on its own over several weeks. If you need a precisely defined shape, filler fits better. If you want to fill a wide area naturally or also improve skin texture, collagen injections fit better.

At a glance

Filler
Hyaluronic acid, immediate volume, can be corrected with a dissolving injection
Collagen injections
Juvelook Volume (PDLLA), Retigen (pure collagen), Colshine, etc.
When changes appear
Filler: immediately / Collagen injections: gradually, from around week 4
Procedure time
About 20 min (plus numbing time)
Recovery
Back to daily life right away; swelling and bruising for a few days
Price
Juvelook Volume 4cc 275,000 KRW (as of the October 2026 menu)

They work differently

Filler creates volume exactly where the hyaluronic acid gel is placed. Results are visible right away and the shape can be finely adjusted. That makes it well suited to areas that need a defined line, such as the nose tip, chin, or under-eye border. Another advantage is that it can be corrected with a dissolving injection if needed.

Collagen injections work slightly differently depending on the ingredient. Pure collagen such as Retigen replenishes collagen directly. PDLLA products such as Juvelook Volume stimulate the body to make new collagen. So the area usually fills in gradually from around week 4, and skin texture and firmness often improve as well.

They also last in different ways. Filler is slowly absorbed over time. With collagen injections, even after the ingredient is absorbed, the collagen made in the meantime often remains, so the change continues. In both cases, however, how long results last varies widely with the area, the amount, and lifestyle.

Which one to choose, and when?

The question we hear most in clinic is "Which one is better?" The answer depends on the area and the result you want. For thin skin such as around the eyes, we mainly recommend Retigen or Colshine. For broadly hollow cheeks and the area around the nasolabial folds, we mainly recommend Juvelook Volume.

  • When filler fits: when shape and lines need to be precise, such as the chin, nose, or under-eye border, or when you want to see results right away
  • When collagen injections fit: when you want to fill a wide area naturally, such as the front cheeks, side cheeks, or temples, or when you're concerned about filler feeling foreign
  • Using both: collagen injections for hollow areas and filler where a line is needed, planned separately

Things to keep in mind

Both procedures can cause swelling, bruising, or lumps at the injection site, and rarely, vascular complications. Collagen injections are often given in divided sessions at intervals rather than all at once, so we adjust the amount while watching the results.

Serene Clinic uses genuine products in the stated amounts as a rule, and we do not recommend more than you need.

Right after the procedure, the injection sites may feel slightly bumpy. With collagen injections, you may be asked to massage the area so the ingredient spreads evenly, so please follow the aftercare instructions.

Prices (as of the October 2026 menu)

Juvelook Volume 4cc (1 session / 3 sessions)275,000 KRW / 690,000 KRW
Juvelook Volume 8cc (1 session / 3 sessions)469,000 KRW / 1,290,000 KRW
Retigen (pure collagen) 2cc550,000 KRW
Colshine (collagen glow) 1cc550,000 KRW
Domestic filler 1cc (4-month retouch)165,000 KRW
Imported filler 1cc (Belotero / Restylane / Juvederm)385,000 KRW / 440,000 KRW / 550,000 KRW

The areas and amounts needed are decided after consultation.

Frequently asked questions

How long do collagen injections last?

It depends on the ingredient and area, but volume that builds up gradually often lasts longer than filler. The exact duration varies from person to person.

Can I get collagen injections where I've had filler?

It's often possible, but we decide after checking the type and amount of your previous filler.

What if I want to see results right away?

Collagen injections show changes over several weeks, so if you need volume right away, filler is more suitable.

This article is general medical information. Results and how long they last vary from person to person. Any treatment can cause side effects such as redness, swelling or pain, so please decide after a consultation.