How do Juvelook Booster and Juvelook Volume differ, and how do you choose between Juvelook and Rejuran?

How does Juvelook change the skin?

Juvelook is an injection that uses slowly dissolving PDLLA particles to stimulate fibroblasts so the skin makes new collagen. PDLLA belongs to the polylactic acid family long used in dissolvable sutures and similar products. Hyaluronic acid is mixed in to make injection smoother and add early hydration.

Juvelook is different from filler, which creates volume as soon as it goes in. The plump feeling right after the injection mostly comes from the added fluid and swelling. The real change appears over several weeks as collagen builds up. So rather than expecting a big change at once, think of Juvelook as a treatment that builds results over several sessions.

What is the difference between Juvelook Booster and Juvelook Volume?

The main difference between Juvelook Booster and Juvelook Volume is injection depth and purpose. Juvelook Booster, listed on our menu as Juvelook Skin, is spread evenly in the upper dermis to improve the quality of the skin itself. Juvelook Volume has larger particles and a thicker concentration, and is placed deeper to restore volume in hollow areas.

Juvelook Skin is injected densely across the whole face, so it suits skin with rough texture, sagging pores, makeup that doesn't sit well, and more fine lines. For thin areas like around the eyes, we use Juvelook Eye separately.

Juvelook Volume is used to fill broad hollow areas naturally, such as the front and side cheeks, temples and around the smile lines. Filler is more precise for areas that need a defined line, like the nose tip or chin, so we sometimes plan the two treatments by area.

For dryness and loss of firmness, which fits better: Juvelook or Rejuran?

If deep dryness and sensitivity are the main concerns, we consider Rejuran first; if firmness and texture are the main concerns, Juvelook Skin. Rejuran Healer uses PN (polynucleotide) and focuses on restoring a damaged dermal environment, so it suits people whose skin has thinned, whose barrier is weak and who flush easily.

Juvelook Skin is closer to adding firm support by prompting new collagen. If your skin is not sensitive but your pores are sagging and it feels less firm, Juvelook Skin may be the better fit.

Many people have both concerns. In that case, we may mix the two in one session or alternate them across sessions. The Juvelook Skin and LilyJuran (a PN product) combination on our menu is designed for this purpose.

• Skin is thin, feels tight and flushes easily: Rejuran Healer
• Pores are sagging, texture is rough and firmness has dropped: Juvelook Skin
• Cheeks and temples are hollow and cast shadows: Juvelook Volume
• Dryness and loss of firmness together: Juvelook Skin combined with a PN product

Are there cases where Juvelook is not a good fit?

If a drooping jawline and sagging cheeks are the main concern, Juvelook alone is not enough. In that case we treat the sagging first with radiofrequency or ultrasound lifting, and use Juvelook as a complement to improve skin quality.

If you have inflamed acne or herpes at the injection site, are pregnant or breastfeeding, or tend to form thick scars such as keloids, we postpone the treatment or discuss other options. If you take blood thinners, you may bruise easily, so please tell us in advance.

Juvelook is also used in treating depressed acne scars, but scars need to be combined with other treatments such as lasers or subcision depending on their type, so we cover them in a separate column.

How many sessions do I need, and when do results appear and how long do they last?

Juvelook builds collagen over several sessions. Studies usually use 3 sessions 4 weeks apart. In a randomized split-face study that used this schedule for Juvelook Volume in the nasolabial folds, improvement held through week 24[1].

Once the swelling right after the injection goes down, the skin may briefly look as it did before, and then texture and firmness slowly improve over 4–8 weeks. In an experiment where PDLLA was injected once into aged mouse skin, collagen and elastin markers were highest at week 8[2]. Juvelook Volume works the same way, with hollow areas filling in as sessions build up.

Results are known to last longer than hyaluronic acid filler, but they vary widely with age, skin thickness, the amount injected, and habits such as sun exposure and smoking. After the initial sessions, we discuss a maintenance session somewhere between a few months and a year, based on your skin.

Do I really need 3 Juvelook Volume sessions exactly one month apart?

Not necessarily. Three sessions 4 weeks apart is the standard schedule used in studies, and no study has yet compared different intervals or sequences. These days at Serene Clinic, we often suggest Juvelook, then Hilowave, then Juvelook again.

PDLLA is a good material for prompting collagen production, but repeating the same stimulus at short intervals does not make results proportionally better. The collagen response from one session keeps growing for several weeks[2]. In our view, adding more stimulus before that response settles may cause tissue to build up firmly in one spot rather than organize evenly.

Hilowave is an injectable based on DHC (dual hyaluronic acid hybrid complex), which combines high- and low-molecular-weight hyaluronic acid with minimally cross-linked hyaluronic acid. In laboratory studies, DHC increased collagen type I/III and elastin production by fibroblasts and lowered aging markers. In UVB-aged rat skin, it reduced wrinkle depth and improved elasticity and collagen density[3].

The response in a fibrosis model is especially interesting. When DHC was injected into mice whose skin had hardened from excess collagen, α-SMA, a marker of myofibroblast activity, went down, and MMP-1, an enzyme that breaks down and rebuilds collagen, went up. Dermal thickness, collagen deposition and skin hardness all decreased[4]. These results suggest that the DHC in Hilowave may not simply increase or suppress collagen. It may help build collagen where it is lacking and help remodel the extracellular matrix (ECM) where it has become too stiff.

So rather than stacking Juvelook every month, we believe this order may help create more natural tissue: Juvelook to start a collagen response, Hilowave to even out the extracellular matrix, then Juvelook again. However, the DHC data come from cell, animal and excised-skin experiments, and no clinical trial has yet compared this sequence directly in people. We decide the number and order of sessions based on skin thickness and how the skin responded to the previous session.

• Session 1, Juvelook (Skin or Volume): stimulates collagen production
• Session 2, Hilowave: remodels the extracellular matrix and hydrates
• Session 3, Juvelook: adds collagen on the evened-out base

Does it hurt, and are there side effects?

Juvelook is injected into the dermis with a needle, so there is a stinging pain. We start after numbing cream has had enough time to absorb, and for Juvelook Skin we choose between hand injection and the X-Injector, which has a cooling function, depending on the area and goal.

Common reactions are red dots at needle sites, small bumps, swelling and bruising, which usually settle within a few days. Rarely, PDLLA particles can gather in one spot and form a small palpable lump, so we avoid injecting too much at once and keep the depth and spacing even. Infection, allergic reactions and, with deeper injections such as Juvelook Volume, vascular complications can also occur in rare cases.

• Skip washing your face and makeup on the day of treatment, and use gentle products from the next day.
• Avoid alcohol, saunas and heavy sweating exercise for 2–3 days.
• Pause scrubs, exfoliants and peels for about 2 weeks.
• Whether to massage depends on the area, so follow the instructions given at your visit.
• Apply moisturizer and sunscreen more carefully than usual.

Prices (as of the October 2026 menu)

The product and amount needed depend on your face and areas of concern, so we explain after your consultation.

Frequently asked questions

References

1. Park JY, Im DJ, Jeon HD, et al. A Split Face Study Comparing the Effect of a PDLLA Based Product and PLLA on the Nasolabial Fold (NLF). Skin Res Technol. 2026;32(1):e70324.
2. Oh S, Seo SB, Kim G, et al. Poly-D,L-Lactic Acid Filler Increases Extracellular Matrix by Modulating Macrophages and Adipose-Derived Stem Cells in Aged Animal Skin. Antioxidants (Basel). 2023;12(6):1204.
3. Roh H, Nguyen NH, Jung J, et al. Regenerative Skin Remodeling by a Dual Hyaluronic Acid Hybrid Complex in Multimodal Preclinical Models. Int J Mol Sci. 2026;27(2):1027.
4. Roh H, Nguyen NH, Jung J, et al. Therapeutic Anti-Fibrotic Effects of a Dual Hyaluronic Acid Hybrid Complex in Bleomycin-Induced Dermal Fibrosis and UVB-Irradiated Human Skin. Int J Mol Sci. 2026;27(7):3038.